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Mouse uPAR / PLAUR Protein, Fc Tag (SPR verified)

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UPR-M5253-100ug
¥3150.00
UPR-M5253-1mg
¥20790.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    uPAR,PLAUR,CD87,MO3

  • 表达区间及表达系统(Source)

    Mouse uPAR Protein, Fc Tag (UPR-M5253) is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Pro 296 (Accession # P35456-1).

    Predicted N-terminus: Leu 24

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    uPAR Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 56.3 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    uPAR SDS-PAGE

    Mouse uPAR Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • 活性(Bioactivity)-SPR

     uPAR SPR

    Human PLAU, His Tag (Cat. No. PLU-H5229) capture on NTA-Series S sensor chip can bind Mouse uPAR Protein, Fc Tag (Cat. No. UPR-M5253) with an affinity constant of 182 nM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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背景介绍

Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.

前沿进展

 
药物研发进展
  • 英文全称:

    Urokinase plasminogen activator surface receptor

  • 中文全称:

    尿激酶型纤溶酶原激活物表面受体

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    7 详情

  • 最高研发阶段:

    临床三期

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