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PSMA

PSMA信息

英文名称:Prostate-Specific Membrane Antigen上市药物数量5
中文名称前列腺癌特异性膜抗原临床药物数量111
靶点别称EC:3.4.17.21，GIG27，Glutamate carboxypeptidase II，NAALADase I，FOLH，Cell growth-inhibiting gene 27 protein，PSM，N-acetylated-alpha-linked acidic dipeptidase I，GCPII，Folylpoly-gamma-glutamate carboxypeptidase，Folate hydrolase 1，FOLH1，Pteroylpoly-Gamma-Glutamate Carboxypeptidase，Membrane Glutamate Carboxypeptidase，Glutamate Carboxypeptidase 2，Glutamate Carboxylase II，NAALAD1，FGCP，PSMA，MGCP，Folate Hydrolase (Prostate-Specific Membrane Antigen) 1，N-Acetylated Alpha-Linked Acidic Dipeptidase 1，Prostate Specific Membrane Antigen Variant F，Prostate-Specific Membrane Antigen，EC 3.4.17.21，NAALAdase，GCP2最高研发阶段Phase 3 Clinical
英文名称:Prostate-Specific Membrane Antigen
中文名称前列腺癌特异性膜抗原
靶点别称EC:3.4.17.21，GIG27，Glutamate carboxypeptidase II，NAALADase I，FOLH，Cell growth-inhibiting gene 27 protein，PSM，N-acetylated-alpha-linked acidic dipeptidase I，GCPII，Folylpoly-gamma-glutamate carboxypeptidase，Folate hydrolase 1，FOLH1，Pteroylpoly-Gamma-Glutamate Carboxypeptidase，Membrane Glutamate Carboxypeptidase，Glutamate Carboxypeptidase 2，Glutamate Carboxylase II，NAALAD1，FGCP，PSMA，MGCP，Folate Hydrolase (Prostate-Specific Membrane Antigen) 1，N-Acetylated Alpha-Linked Acidic Dipeptidase 1，Prostate Specific Membrane Antigen Variant F，Prostate-Specific Membrane Antigen，EC 3.4.17.21，NAALAdase，GCP2
上市药物数量5
临床药物数量111
最高研发阶段Phase 3 Clinical

PSMA产品列表

  • 属性

    Protein (13)Beads (1)Antibody (1)Cell (1)

  • 产品库

    在线 (16)

  • 物种

    Human (8)Cynomolgus (2)Mouse (4)Rat (1)Rabbit (1)

  • 标签

    His Tag (6)His Tag & Avi Tag (3)Fc Tag (2)- (3)Fc Tag & Avi Tag (2)

  • 标记

    Unconjugated (7)Biotin-labeled (5)FITC Labeled (1) (2)PE Labeled (1)

共 16 项数据
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  • 2

PSMA分子背景

Prostate-specific membrane antigen (PSMA) is also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1), which belongs to the peptidase M28 family and M28B subfamily. FOLH1 / PSMA is stable at pH greater than 6.5. FOLH1 / PSMA is a type II transmembrane zinc metallopeptidase that is most highly expressed in the nervous system, prostate, kidney, and small intestine. FOLH1 / GCP-2 is homodimer and binds 2 zinc ions per subunit, and required for NAALADase activity. The catalytic activity of PSMA involved in releasing of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly – gamma - glutamates. FOLH1 / GCP-2 / PSMA has both folate hydrolase and N – acetylated – alpha – linked - acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. GCP-2 / PSMA involved in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

PSMA分子别名

FOLH1,PSMA,GIG27,FOLH,NAALAD1,PSM,NAALADase I,GCPII,FGCP

产品评论

  • 25********qq.com 2025-02-24
    0人点赞
    Cynomolgus PSMA / FOLH1 Protein, His Tag (active enzyme, MALS verified)
    采购Cynomolgus PSMA蛋白主要用于抗体筛选实验，经实验验证，ACRO提供的重组蛋白具有优异的批次间一致性和稳定性，在靶点-抗体互作实验中表现出高度可靠的实验重复性，所获数据信噪比理想，为抗体筛选及功能验证提供了坚实的技术支持。
  • 22********qq.com 2025-02-20
    0人点赞
    Mouse PSMA / FOLH1 Protein, His Tag (active enzyme) (MALS verified)
    购买鼠源FOLH1蛋白主要用于噬菌体展示纳米抗体库的筛选，百普塞斯蛋白质量不仅有保障，发货速度也是非常迅速，一般都是申购次日就能收到蛋白。蛋白含有his tag，用起来方便，铺板效果也很好，性价比高，很实用。
  • 22********qq.com 2025-02-20
    0人点赞
    Cynomolgus PSMA / FOLH1 Protein, His Tag (active enzyme, MALS verified)
    购买该蛋白主要用于抗体亲和力检测，使用BLI方法检测抗原抗体结合KD数据。首先将蛋白固定在芯片上，再与抗体进行结合，蛋白活性稳定，固化效果不错，与抗体结合迅速，KD数据很理想，值得点赞。
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