GMP Human Laminin 521 Protein

GMP Human Laminin 521 Protein (GMP Laminin 521) is a recombinant human protein that provides a defined surface for in vitro feeder-free culture of multiple human pluripotent stem cells (PSCs). GMP Laminin 521 has been proven to maintain normal growth characteristics and stemness in multiple PSC lines without simultaneous differentiation, which includes ESC, iPSC, MSC, etc. In addition, GMP Laminin 521 has been demonstrated to support PSC growth for >10 passages without any signs of karyotypic abnormalities and to maintain the ability of PSCs to differentiate into all three germ line lineages.
High-quality products and regulatory support files are essential for the smooth transition from preclinical research & development to cell therapy clinical study. Designed for clinical research, GMP Laminin 521 is manufactured by an animal-free process in a GMP-compliant facility. A full battery of QC testing is implemented to ensure product quality, including purity, bioactivity, sterility, mycoplasma, endotoxin, etc. GMP Laminin 521 protein (GMP-LA5H24) is the GMP version of laminin 521 protein premium grade (LA5-H5261), and they have exactly the same performance for seamless transition.
This product is designed and developed utilizing our proprietary AI technology, which is protected by patent rights. We retain full commercial rights to this product.

• High Performance: Facilitates the rapid expansion and stemness maintenance of hPSC after several passages.
• Optimal Adhesion: Maintains good cell adhesion characteristics at concentrations as low as 2 μg/mL.
• Comprehensive Safety Assurance: ECACC-compliant HEK293 host cell origin and comprehensive testing (28 items), animal-origin-free (AOF) production process, dual virus reduction measures, and comprehensive viral clearance validation.
• Lot-to-Lot Consistency: Achieved through a stable cell line and robust process, ensuring reliable performance from research to clinical manufacturing.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

HEK293

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped with blue ice, please inquire the shipping cost.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.