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Alpha-synuclein

Alpha-synuclein信息

英文名称:Synuclein alpha上市药物数量0
中文名称α-突触核蛋白临床药物数量23
靶点别称Truncated Alpha Synuclein，Α-Synuclein，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，α-Synuclein，PARK4，PD1，alpha-Synuclein，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，Non A-Beta Component Of AD Amyloid，PARK1，SNCA，Synuclein Alpha，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor最高研发阶段Phase 3 Clinical
英文名称:Synuclein alpha
中文名称α-突触核蛋白
靶点别称Truncated Alpha Synuclein，Α-Synuclein，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，α-Synuclein，PARK4，PD1，alpha-Synuclein，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，Non A-Beta Component Of AD Amyloid，PARK1，SNCA，Synuclein Alpha，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor
上市药物数量0
临床药物数量23
最高研发阶段Phase 3 Clinical

Alpha-synuclein产品列表

  • 属性

    Protein (13)Cell (1)

  • 产品库

    在线 (14)

  • 物种

    Human (12)Cynomolgus (1)Mouse (1)

  • 标签

    His Tag (5)His Tag & Avi Tag (1)Fc Tag (1)Tag Free (6)GFP Tag (1)

  • 标记

    Unconjugated (11)Biotin-labeled (1) (1)AF488 Labeled (1)

共 14 项数据
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Alpha-synuclein分子背景

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Alpha-synuclein分子别名

NACP, PARK1, PARK4, PD1

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