Human Laminin 511 Protein, premium grade (Mix & Scale)

Human Laminin 511 Protein, premium grade (Mix & Scale) is a recombinant human laminin 511 E8 (LN511-E8) protein that provides a defined surface for in vitro feeder-free culture of multiple human pluripotent stem cells (PSCs).
As published by Takamichi Miyazaki et al., the LN511-E8 variant of laminin 511 shows higher efficiency for supporting the adhesion of dissociated cells than did wild-type laminin 511 which makes it a cost-effective choice.
LN511-E8 has been proven to maintain normal growth characteristics and stemness in multiple PSC lines without simultaneous differentiation, which includes ESC, iPSC, MSC, etc. In addition, LN511-E8 has been demonstrated to support PSC growth for > 10 passages without any signs of karyotypic abnormalities and to maintain the ability of PSCs to differentiate into all three germ line lineages.
This product is designed and developed utilizing our proprietary AI technology, which is protected by patent rights. We retain full commercial rights to this product.
Importantly, our innovative laminin 511 protein (Mix & Scale) could meanwhile support pre-coating method and suspension method (directly mixing the protein with cell suspensions without coating plates).
No coating steps are needed and easy scale-up
Simplified operation and support automated manufacturing at a large scale.
Cost-effective
Significant cost reduction compared to classic coating method.
Stemness maintenance
No spontaneous differentiation is observed after several passages of hPSC culture.
Lot-to-lot consistency
Produced from a stable cell line, robust purification process, and stringent QC.
Ready to scale supply
A new cGMP-compliant facility is ready and supports large scale manufacutring supply.

• Seamless Transition from Preclinical to Clinical: Same cell clone, process, and QC as GMP products.
• Enhanced Production Standards: AOF raw materials, pharma-grade excipients, Grade B+A (ISO 5) environment.
• Comprehensive Quality Control: Additional strict testing for process impurities, sterility, and mycoplasma.
• Cost-Effective Solution: GMP-comparable quality at an economical price for early development.
• Risk Mitigation: Enhanced safety through rigorous impurity control and comprehensive testing.

CHO

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

This product is supplied and shipped with dry ice, please inquire the shipping cost.

For long term storage, the product should be stored at liquid state at -20℃ or below.

Please avoid repeated freeze-thaw cycles.

• 2-8°C for 6 months under sterile conditions;
• -20°C or below for 3 years.

ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration, followed by lyophilization where applicable. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.