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Rat TSLP Protein, His Tag

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TSP-R52H3-100ug
¥3675.00
TSP-R52H3-1mg
¥24255.00
合计0件 产品金额¥ 0

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  • 分子别名(Synonym)

    TSLP

  • 表达区间及表达系统(Source)

    Rat TSLP, His Tag (TSP-R52H3) is expressed from human 293 cells (HEK293). It contains AA Tyr 18 - Ser 135 (Accession # A0A0G2JUJ3-1).

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    TSLP Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 15.5 kDa. The protein migrates as 20-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    TSLP SDS-PAGE

    Rat TSLP, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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背景介绍

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

前沿进展

 
药物研发进展
  • 英文全称:

    Thymic stromal lymphopoietin

  • 中文全称:

    胸腺基质淋巴细胞生成素

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    23 详情

  • 最高研发阶段:

    批准上市

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