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Mouse TPBG / 5T4 Protein, His Tag (MALS verified)

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TPG-M52H3-100ug
¥3675.00
TPG-M52H3-1mg
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein

  • 表达区间及表达系统(Source)

    Mouse TPBG, His Tag (TPG-M52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 32 - Ser 361 (Accession # Q9Z0L0-1).

    Predicted N-terminus: Ser 32

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    TPBG Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 37.7 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    95% as determined by SDS-PAGE.

    90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    TPBG SDS-PAGE

    Mouse TPBG, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    TPBG SEC-MALS

    The purity of Mouse TPBG, His Tag (Cat. No. TPG-M52H3) is more than 90% and the molecular weight of this protein is around 53-65 kDa verified by SEC-MALS.

    Report

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背景介绍

Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.

前沿进展

 
药物研发进展
  • 英文全称:

    Trophoblast glycoprotein

  • 中文全称:

    5T4滋养层糖蛋白

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    14 详情

  • 最高研发阶段:

    临床二期

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