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Rat PTK7 / CCK4 Protein, His Tag (MALS verified)

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PT7-R52H6-100ug
¥3675.00
PT7-R52H6-1mg
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7

  • 表达区间及表达系统(Source)

    Rat PTK7, His Tag (PT7-R52H6) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Gln 695 (Accession # NP_001382670.1).

    Predicted N-terminus: Ala 23

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    PTK7 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 76.1 kDa. The protein migrates as 95-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    95% as determined by SDS-PAGE.

    90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    PTK7 SDS-PAGE

    Rat PTK7, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    PTK7 SEC-MALS

    The purity of Rat PTK7, His Tag (Cat. No. PT7-R52H6) is more than 90% and the molecular weight of this protein is around 85-115 kDa verified by SEC-MALS.

    Report

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背景介绍

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

前沿进展

 
药物研发进展
  • 英文全称:

    Protein-tyrosine kinase 7

  • 中文全称:

    蛋白酪氨酸激酶-7

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    3 详情

  • 最高研发阶段:

    临床二期

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