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Mouse NCAM-1 / CD56 Protein, His Tag

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NC1-M52H4-100ug
¥3675.00
NC1-M52H4-1mg
¥24255.00
合计0件 产品金额¥ 0

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  • 分子别名(Synonym)

    CD56,MSK39,NCAM1,N-CAM-1

  • 表达区间及表达系统(Source)

    Mouse NCAM-1, His Tag (NC1-M52H4) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Thr 711 (Accession # P13595-1).

    Predicted N-terminus: Leu 20

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    NCAM-1 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 78.5 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 500 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    NCAM-1 SDS-PAGE

    Mouse NCAM-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

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背景介绍

NCAM1 belongs to the immunoglobulin superfamily of adhesion molecules. A wide range of alternatively spliced NCAM1 messenger RNAs (mRNAs) has been described to date, but only the 120-, 140-, and 180- kDa isoforms are commonly expressed. NCAM1 plays an important role in the regulation of neurogenesis, neurite outgrowth, proliferation, and cell migration, however, its function in hematopoiesis, including NK cells, is poorly understood. NCAM1 signaling is mediated either by homophilic or heterophilic interactions with fibroblast growth factor receptor (FGFR), L1-CAM, N-cadherin and other components of the extracellular matrix. Upon activation, NCAM1 triggers a variety of signaling cascades including FYN–focal adhesion kinase (FAK), MAPK, and phosphatidylinositol 3-kinase (PI3K) pathways.

前沿进展

 
药物研发进展
  • 英文全称:

    Neural cell adhesion molecule 1

  • 中文全称:

    神经细胞粘附分子-1

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    5 详情

  • 最高研发阶段:

    临床二期

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