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Mouse LY75 / CD205 Protein, His Tag (MALS verified)

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LY5-M52H5-1mg (250ug X 4)
¥24255.00
LY5-M52H5-100ug
¥3675.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    LY75,CD205,DEC-205,CLEC13B,Lymphocyte antigen 75,gp200-MR6

  • 表达区间及表达系统(Source)

    Mouse LY75, His Tag (LY5-M52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 28 - Asp 1667 (Accession # Q60767-1).

    Predicted N-terminus: Ser 28

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    LY75 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 190.0 kDa. The protein migrates as 230-260 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

    90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    LY75 SDS-PAGE

    Mouse LY75, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    LY75 SEC-MALS

    The purity of Mouse LY75, His Tag (Cat. No. LY5-M52H5) is more than 90% and the molecular weight of this protein is around 210-255 kDa verified by SEC-MALS.

    Report

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背景介绍

lymphocyte antigen 75 (Ly 75, also known as CD205, CLEC13B, GP200-MR6 and DEC-205, is a type I transmembrane protein that is primarily expressed on dendritic cells and thymic epithelial cells. LY75 functions as an endocytic receptor for antigens. MEN1309/OBT076, the first antibody drug targeting CD205, has shown strong preclinical anti-tumor activity in lymphoma. After being verified as a single drug in vivo, the antibody-drug conjugate has a synergistic effect with the BCL2 inhibitor Venetoclax and the anti-cd20 monoclonal antibody rituximab.

前沿进展

 
药物研发进展
  • 英文全称:

    Lymphocyte antigen 75

  • 中文全称:

    淋巴细胞抗原-75

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    2 详情

  • 最高研发阶段:

    临床二期

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