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Cynomolgus / Rhesus macaque IL-15 Protein, His Tag

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IL5-C52H4-50ug
¥4200.00
IL5-C52H4-1mg
¥29400.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IL-15,Interleukin-15,MGC9721

  • 表达区间及表达系统(Source)

    Cynomolgus / Rhesus macaque IL-15, His Tag (IL5-C52H4) is expressed from human 293 cells (HEK293). It contains AA Asn 49 - Ser 162 (Accession # P48092-1).

    Predicted N-terminus: Asn 49

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-15 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 14.9 kDa. The protein migrates as 14 kDa and 16-18 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    IL-15 SDS-PAGE

    Cynomolgus / Rhesus macaque IL-15, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • 活性(Bioactivity)-ELISA

     IL-15 ELISA

    Immobilized Human IL-15 R alpha, Fc Tag (Cat. No. ILA-H5253) at 2 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque IL-15, His Tag (Cat. No. IL5-C52H4) with a linear range of 1-8 ng/mL (QC tested).

    Protocol
  •  IL-15 ELISA

    Immobilized Anti-IL-15 Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque IL-15, His Tag (Cat. No. IL5-C52H4) with a linear range of 2-16 ng/mL (Routinely tested).

    Protocol
  •  IL-15 ELISA

    Immobilized Cynomolgus / Rhesus macaque IL-15, His Tag (Cat. No. IL5-C52H4) at 2 μg/mL (100 μL/well) can bind Human IL-2RB&IL-2RG Heterodimer Protein, Fc Tag&Fc Tag (MALS verified) (Cat. No. ILG-H5254) with a linear range of 0.039-0.625 μg/mL (Routinely tested).

    Protocol
  •  IL-15 ELISA

    Immobilized Cynomolgus / Rhesus macaque IL-15, His Tag (Cat. No. IL5-C52H4) at 2 μg/mL (100 μL/well) can bind Human IL-2RB&IL-2RA&IL-2RG, Fc Tag&Fc Tag (Cat. No. ILG-H5257) with a linear range of 0.078-1.25 μg/mL (Routinely tested).

    Protocol

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背景介绍

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin-15

  • 中文全称:

    白细胞介素-15

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    19 详情

  • 最高研发阶段:

    临床二期

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