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Human ErbB3 / Her3 Protein, His Tag (MALS verified)

COAMS
DS
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货号-规格
价格
Qty.
ER3-H5223-100ug
¥2730.00
ER3-H5223-1mg (500ug X 2)
¥15120.00
合计0件 产品金额¥ 0
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产品详情

  • 分子别名（Synonym）

    ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3

  • 表达区间及表达系统（Source）

    Human ErbB3, His Tag (ER3-H5223) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Thr 643 (Accession # P21860-1).

    Predicted N-terminus: Ser 20

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    ErbB3 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 70.5 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 0.1 EU per μg by the LAL method.

  • 纯度（Purity）

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    ErbB3 SDS-PAGE

    Human ErbB3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    ErbB3 SEC-MALS

    The purity of Human ErbB3, His Tag (Cat. No. ER3-H5223) is more than 90% and the molecular weight of this protein is around 75-100 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）-ELISA

    ErbB3 ELISA

    Immobilized Human ErbB3, His Tag (Cat. No. ER3-H5223) at 2 μg/mL (100 μL/well) can bind Human NRG1 Beta 1, Fc Tag, premium grade (Cat. No. NR1-H5268) with a linear range of 0.1-3 ng/mL (QC tested).

    Protocol

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背景介绍

ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

前沿进展

 
药物研发进展
  • 英文全称：

    Receptor tyrosine-protein kinase erbB-3

  • 中文全称：

    受体酪氨酸蛋白激酶erbB-3

  • 种类：

  • 上市药物数量：

    2 详情

  • 临床药物数量：

    25 详情

  • 最高研发阶段：

    批准上市

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