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Rhesus macaque CTGF / CCN2 Protein, His Tag

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GTF-R52H4-100ug
¥3675.00
GTF-R52H4-1mg (500ug X 2)
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

  • 表达区间及表达系统(Source)

    Rhesus macaque CTGF, His Tag (GTF-R52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Ala 349 (Accession # H9FQD5-1).

    Predicted N-terminus: Gln 27

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CTGF Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 37.3 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 5 mM HAC, 100 mM NaCl, pH5.5 with Sucrose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    CTGF SDS-PAGE

    Rhesus macaque CTGF, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • 活性(Bioactivity)-ELISA

     CTGF ELISA

    Immobilized Rhesus macaque CTGF, His Tag (Cat. No. GTF-R52H4) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CTGF Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

    Protocol

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背景介绍

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

前沿进展

 
药物研发进展
  • 英文全称:

    Connective tissue growth factor

  • 中文全称:

    结缔组织生长因子

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    5 详情

  • 最高研发阶段:

    批准上市

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