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Human Claudin-6 / CLDN6 Full Length Protein (VLP)

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CL6-H52P7-20ug
¥5250.00
CL6-H52P7-100ug
¥10500.00
CL6-H52P7-500ug (250ug X 2)
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产品详情

  • 分子别名（Synonym）

    Claudin-6,CLDN6

  • 表达区间及表达系统（Source）

    Human Claudin-6 Full Length Protein (VLP) (CL6-H52P7) is expressed from human 293 cells (HEK293). It contains AA Met 1 -Val 220 (Accession # P56747).

    Predicted N-terminus: Met 1

  • 蛋白结构（Molecular Characterization）

    Virus-like particles(VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.

    The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 制剂（Formulation）

    The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

    Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程
  • *The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow this link for product information.

产品展示

  • 活性（Bioactivity）-ELISA

    Claudin-6 ELISA

    Immobilized Human Claudin-6 Full Length Protein (VLP) (Cat. No. CL6-H52P7) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human Claudin-6 antibody, Human IgG1 with a linear range of 0.1-1 ng/mL (QC tested).

    Protocol

  • 活性（Bioactivity）-SPR

    Claudin-6 SPR

    Human Claudin-6 Full Length Protein (VLP) (Cat. No. CL6-H52P7) captured on L1 Chip can bind Anti-Claudin-6 Antibody, Human IgG1 with an affinity constant of 57.8 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

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背景介绍

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-6, also knows as CLDN6, is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. And it is one of the entry cofactors for hepatitis C virus. The methylation of CLDN6 may be involved in esophageal tumorigenesis. The gene of CLDN6 is adjacent to another family member CLDN9 on chromosome 16.

前沿进展

 
药物研发进展
  • 英文全称：

    Claudin 6

  • 中文全称：

    紧密连接蛋白6

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    10 详情

  • 最高研发阶段：

    临床二期

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