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Human CD79B Protein, Fc Tag

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CDB-H5259-100ug
¥3045.00
CDB-H5259-1mg
¥18900.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CD79b,B29,IGB,Ig-beta

  • 表达区间及表达系统(Source)

    Human CD79B, Fc Tag (CDB-H5259) is expressed from human 293 cells (HEK293). It contains AA Ala 29 - Asp 159 (Accession # P40259-1).

    Predicted N-terminus: Ala 29

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CD79B Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 41.8 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 0.1 EU per μg by the LAL method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    CD79B SDS-PAGE

    Human CD79B, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • 活性(Bioactivity)-ELISA

     CD79B ELISA

    Immobilized Human CD79B, Fc Tag (Cat. No. CDB-H5259) at 1 μg/mL (100 μL/well) can bind Anti-CD79B (Polatuzumab) Humanized Antibody with a linear range of 0.1-1 ng/mL (Routinely tested).

    Protocol

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背景介绍

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

前沿进展

 
药物研发进展
  • 英文全称:

    B-cell antigen receptor complex-associated protein beta chain

  • 中文全称:

    B细胞抗原受体复合物相关蛋白β链

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    8 详情

  • 最高研发阶段:

    批准上市

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