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Human CD46 Protein, His Tag (MALS verified)

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CD6-H5226-50ug
¥3310.00
CD6-H5226-1mg (500ug X 2)
¥22050.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CD46,AHUS2,MCP,MIC10,TLX,TRA2.10

  • 表达区间及表达系统(Source)

    Human CD46, His Tag (CD6-H5226) is expressed from human 293 cells (HEK293). It contains AA Cys 35 - Asp 328 (Accession # P15529-3).

    Predicted N-terminus: Cys 35

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CD46 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 33.6 kDa. The protein migrates as 45-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    CD46 SDS-PAGE

    Human CD46, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD46 SEC-MALS

    The purity of Human CD46, His Tag (Cat. No. CD6-H5226) is more than 95% and the molecular weight of this protein is around 40-55 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     CD46 ELISA

    Immobilized Human CD46, His Tag (Cat. No. CD6-H5226) at 1 μg/mL (100 μL/well) can bind FG-3246 (FOR46), Human IgG1 kappa with a linear range of 0.3-2 ng/mL (QC tested).

    Protocol

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背景介绍

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

前沿进展

 
药物研发进展
  • 英文全称:

    Membrane cofactor protein

  • 中文全称:

    膜辅因子蛋白

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    3 详情

  • 最高研发阶段:

    临床二期

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