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Human CCL3 / MIP-1 alpha Protein, His Tag

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货号-规格
价格
Qty.
CC3-H5249-20ug
¥1890.00
CC3-H5249-50ug
¥3780.00
CC3-H5249-1mg (500ug X 2)
¥31500.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    C-C motif chemokine 3,MIP1-(a),AI323804,CCL3,chemokine (C-C motif) ligand 3,G0S19-1,LD78a,LD78alpha,MIP1 alpha,MIP-1 alpha,MIP1A,MIP-1alpha,MIP1-alpha

  • 表达区间及表达系统(Source)

    Human CCL3, His Tag (CC3-H5249) is expressed from E. coli cells. It contains AA Ser 24 - Ala 92 (Accession # P10147-1).

    Predicted N-terminus: Met

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CCL3 Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 9.7 kDa. The protein migrates as 12-13 kDa under reducing (R) condition (SDS-PAGE).

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 0.1 EU per μg by the LAL method.

  • 纯度(Purity)

    95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris,150 mM NaCl,0.2 M Arginine,pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    CCL3 SDS-PAGE

    Human CCL3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

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背景介绍

CCL3, also know as MIP-1-alpha, is monokine with inflammatory and chemokinetic properties. CCL3 is an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

前沿进展

 
药物研发进展
  • 英文全称:

    Macrophage inflammatory protein 1-α

  • 中文全称:

    巨噬细胞炎性蛋白-1α

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    0 详情

  • 最高研发阶段:

    临床前

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