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Human Cathepsin S / CTSS Protein, His Tag (active enzyme, MALS verified)

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CTS-H52H9-50ug
¥3045.00
CTS-H52H9-1mg
¥18900.00
合计0件 产品金额¥ 0
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产品详情

  • 分子别名（Synonym）

    CTSS,Cathepsin S

  • 表达区间及表达系统（Source）

    Human Cathepsin S, His Tag (CTS-H52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 17 - Ile 331 (Accession # P25774-1).

    Predicted N-terminus: Gln 17

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    Cathepsin S Structure

    This protein carries a polyhistidine tag at the C-terminus. This protein contains an Activation peptide(17 Q-114 I), and will be partially processed into Pro form with calculated MW of 39 kDa and mature form with calculated MW of 28 kDa under reducing (R) condition.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    90% as determined by SDS-PAGE.

    90% as determined by SEC-MALS.

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in 12.5 mM MES, 75 mM NaCl, pH6.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    Cathepsin S SDS-PAGE

    Human Cathepsin S, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%undefined.

  • SEC-MALS

    Cathepsin S SEC-MALS

    The purity of Human Cathepsin S, His Tag (Cat. No. CTS-H52H9) is more than 90% and the molecular weight of this protein is around 70-92 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）

    Measured by its ability to cleave the fluorogenic peptide substrate, Mca­RPKPVE­Nval­WRK(Dnp)­NH2. The specific activity is >1200 pmol/min/µg, as measured under the described conditions (QC tested).

    Protocol

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背景介绍

Cathepsin S is also known as CTSS, which is a member of the peptidase C1 family. Cathepsin S is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. The catalytic activity of cathepsin S is similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.

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药物研发进展
  • 英文全称：

    Cathepsin S

  • 中文全称：

    组织蛋白酶S

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    1 详情

  • 最高研发阶段：

    临床一期

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