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PE-Labeled Human BCMA / TNFRSF17 Protein, His Tag (Site-specific conjugation)DMF

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BCA-HP2H2-25tests
¥3695.00
BCA-HP2H2-200tests
¥22930.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    TNFRSF17,CD269,BCM,BCMA

  • 表达区间及表达系统(Source)

    PE-Labeled Human BCMA, His Tag (BCA-HP2H2) is produced via site-specific conjugation of PE to Human BCMA, His Tag under optimal conditions with a proprietary technology. Human BCMA, His Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54 (Accession # Q02223-1).

    Predicted N-terminus: Met 1

    Request for sequence

  • 蛋白结构(Molecular Characterization)

    BCMA Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 10 kDa.

  • 偶联(Conjugate)

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • 应用说明(Application)

    Please note that this product is NOT compatible to streptavidin detection system.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS,pH7.4,BSA.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 6 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 活性(Bioactivity)-FACS

     BCMA FACS

    1e6 of the Anti-BCMA CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human BCMA Protein, His Tag (Cat. No. BCA-HP2H2) and negative control protein respectively, PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

前沿进展

 
药物研发进展
  • 英文全称:

    B-cell maturation protein

  • 中文全称:

    B细胞成熟蛋白

  • 种类:

  • 上市药物数量:

    7 详情

  • 临床药物数量:

    117 详情

  • 最高研发阶段:

    临床三期

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