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Mouse BAFFR / TNFRSF13C Protein, His Tag (MALS verified)

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BAR-M52H8-100ug
¥3675.00
BAR-M52H8-1mg (500ug X 2)
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

  • 表达区间及表达系统(Source)

    Mouse BAFFR, His Tag (BAR-M52H8) is expressed from human 293 cells (HEK293). It contains AA Ser 10 - Ala 71 (Accession # Q3SXS6-1).

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    BAFFR Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 8.7 kDa. The protein migrates as 15-20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

    90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    BAFFR SDS-PAGE

    Mouse BAFFR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    BAFFR SEC-MALS

    The purity of Mouse BAFFR, His Tag (Cat. No. BAR-M52H8) is more than 90% and the molecular weight of this protein is around 9-18 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     BAFFR ELISA

    Immobilized Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) at 1 μg/mL (100 μL/well) can bind Mouse BAFFR, His Tag (Cat. No. BAR-M52H8) with a linear range of 2-63 ng/mL (QC tested).

    Protocol

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背景介绍

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

前沿进展

 
药物研发进展
  • 英文全称:

    B-cell activating factor receptor

  • 中文全称:

    B细胞活化因子受体

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    7 详情

  • 最高研发阶段:

    临床三期

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