选择语言

PE-Labeled Human B7-H3 (4Ig) / B7-H3b Protein, His Tag (Site-specific conjugation)

用户评价
货号-规格
价格
Qty.
B7B-HP2H9-25tests
¥3520.00
B7B-HP2H9-200tests
¥21840.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    4Ig-B7-H3,B7-H3,CD276,PSEC0249,UNQ309,PRO352,B7 homolog 3

  • 表达区间及表达系统(Source)

    PE-Labeled Human B7-H3 (4Ig), His Tag (B7B-HP2H9) is produced via site-specific conjugation of PE to Human B7-H3 (4Ig), His Tag under optimal conditions with a proprietary technology. Human B7-H3 (4Ig), His Tag is expressed from human 293 cells (HEK293). It contains AA Gly 27 - Thr 461 (Accession # Q5ZPR3-1).

    Predicted N-terminus: Gly 27

    Request for sequence

  • 蛋白结构(Molecular Characterization)

    B7-H3 (4Ig) Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 50.3 kDa.

  • 偶联(Conjugate)

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • 应用说明(Application)

    Please note that this product is NOT compatible to streptavidin detection system.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

产品展示

  • 活性(Bioactivity)-FACS

     B7-H3 (4Ig) FACS

    5e5 of anti-B7-H3 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human B7-H3 (4Ig), His Tag (Cat. No. B7B-HP2H9) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

用户评价
发表评论

背景介绍

Human B7 homolog 3 (B7-H3) is a member of the B7 family of immune proteins that provide signals for the regulation of immune responses. Other family members include B7-1, B7-2, B7-H1/PD-L1, B7-H2, and PD-L2. B7 family proteins are type I transmembrane immunoglobulin (Ig) superfamily members that contain extracellular Ig V‑like and Ig C‑like domains with a short cytoplasmic tail. Termed 4IgB7-H3 or B7-H3b, this molecule has two additional Ig-like domains (one V‑type and one C‑type) and shows a ubiquituous expression pattern.

前沿进展

 
药物研发进展
  • 英文全称:

    CD276 antigen

  • 中文全称:

    CD276抗原

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    45 详情

  • 最高研发阶段:

    申请上市

联系我们
项目合作
查看更多项目
  • 产品SKU
  • 产品详情
  • 产品展示
  • 用户评价
  • 背景介绍