选择语言

HEK293/Human Cadherin-17 Stable Cell Line

用户评价
货号-规格
价格
Qty.
CHEK-ATP173-2Vials (1Vial X 2)
询价
合计0件 产品金额¥ 0

产品详情

    1. Genetically modified cell lines best reflect MOA (Mechanism of Action)
    2. Higher activity and larger assay window for robust and reproducible cell-based bioassay
    3. Comprehensive application data to support assay development and validation
    4. Full tracible record, stringent quality control and validated cell passage stability
    5. Parental cell line legally obtained from internationally recognized cell resource bank and commercially licensed
    6. Global commercial license assistance whenever regulatory filing is required
  • 描述(Description)

    The HEK293/Human Cadherin-17 Stable Cell Line was engineered to express the full length human Cadherin-17 (Uniprot: Q12864), used to mimic cancer target cells. Surface expression of human Cadherin-17 was confirmed by flow cytometry.

  • 应用说明(Application)

    •        Useful for cell-based Cadherin-17 binding assay

  • 生长特性(Growth Properties)

    Adherent

  • 筛选标记(Selection Marker)

    Puromycin (2 μg/mL)

  • 培养基(Complete Growth Medium)

    DMEM + 10% FBS

  • 冻存液(Freeze Medium)

    Serum-free cell cryopreservation medium

  • 装量(Quantity)

    1 vial contains at least 5×10^6 cells in 1 mL serum-free cryopreservation medium

  • 存储(Storage)

    Frozen in liquid nitrogen.

  • 支原体检测(Mycoplasma Testing)

    Negative

  • 无菌检测(Sterility Testing)

    Negative

  • 使用说明(Instructions for Use)

    See data sheet for detailed culturing and assay protocol.

产品展示

  • Receptor Assay

     Cadherin-17 FACS

    Expression analysis of human Cadherin-17 on HEK293/Human Cadherin-17 Stable Cell Line by FACS.
    Cell surface staining was performed on HEK293/Human Cadherin-17 Stable Cell Line or negative control cell using anti-human Cadherin-17 antibody followed by staining with FITC anti-mouse IgG antibody.

    Protocol
*如有相关细胞池需求请联系我们

用户评价
发表评论

背景介绍

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

前沿进展

 
药物研发进展
  • 英文全称:

    Cadherin-17

  • 中文全称:

    钙粘蛋白17

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    6 详情

  • 最高研发阶段:

    临床二期

联系我们
项目合作
查看更多项目
  • 产品SKU
  • 产品详情
  • 产品展示
  • 用户评价
  • 背景介绍