CD45 詳細
Molecule Name
Leukocyte common antigen
分子の別称
CD45,PTPRC,L-CA,T200
Drug Development Progress
治験薬の数7
市販薬剤の数0
研究＆開発段階Phase 3 Clinical
ターゲットの別称
PTPRC，T200，CD45，Protein Tyrosine Phosphatase， Receptor Type C，CD45 Antigen，L-CA，Protein Tyrosine Phosphatase， Receptor Type， C Polypeptide，Receptor-Type Tyrosine-Protein Phosphatase C，T200 Leukocyte Common Antigen，Leukocyte Common Antigen，T200 Glycoprotein，EC 3.1.3.48，CD45R，GP180，B220，LCA，LY5，Leukocyte Common Antigens，Protein Tyrosine Phosphatase Receptor Type C，EC:3.1.3.48
バックグランド
CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
CD45 製品リスト
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n***l2025-10-31The technical team was quick to respond to my question regarding my experimental plan to use the biotinylated CD45 PTPRC protein. The biotinylated protein was immobilized on the SA biosensor of Octet BLI R8 to measure the binding affinity of anti-human CD45RA antibody. The assay worked on the first try!- N***o2023-05-13We were very satisfied with the whole process of purchasing and utilizing the product as we had no issues with shipping time or product packaging. We used the protein to assist in the development of LFAs detecting for CD45 on cells. Pairs of anti-CD45 antibodies were first tested using the protein to help us determine which pair of antibodies produced the best results. These tests allowed us to move forward with designing full LFAs.
- L***h2021-12-13Dear Sir or Madam, I had an overall good service from Acro Biosystems. Shipment was fast and product quality was good. Got the protocol for QC after asking the customer service. Protocol for QC was easy to understand and repeat. Easy way to download the Certificate of Analysis via the printed QR code on product vials. Customer service answered very fast and was very friendly. QC of biotinylated human CD45 protein vs. Human Galectin-1 protein (GA1-H4113) was fine. Biotinylated human CD45 protein worked fine and could be loaded on Streptavidin biosensors (Octet system).