CA125 詳細
Molecule Name
Mucin-16
分子の別称
CA125,CA-125,CA125MUC-16,FLJ14303,MUC16,mucin 16,mucin-16
Drug Development Progress
治験薬の数11
市販薬剤の数0
研究＆開発段階Phase 3 Clinical
ターゲットの別称
Mucin-16 Short Isoform，Mucin-16 Long Isoform，Ovarian carcinoma antigen CA125，Ovarian cancer-related tumor marker CA125，MUC16，MUC-16，CA-125，Mucin 16， Cell Surface Associated，CA125，CA125 Ovarian Cancer Antigen，Mucin-16，CA-125 Antigen，FLJ14303
バックグランド
The CA125, also known as the MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. The CA 125 molecule is almost certainly a glycoprotein with a predominance of O-linkages. It is heterogeneous with regard to both size and charge, most likely due to continuous deglycosylation of side chains during its life-span in bodily fluids. It exists as a very large complex (perhaps as much as 4 million daltons) under natural conditions.
CA125 製品リスト
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E***e2025-08-07We used Acro Biosystems' recombinant Human CA125 / MUC16 protein (Catalog #CA5-H52H6) as a target antigen for antibody screening and downstream validation. The protein was employed in both ELISA and FACS assays. In ELISA, we observed strong, dose-dependent binding with minimal background, which enabled clear differentiation of candidate clones. For FACS, we used the protein to confirm surface staining specificity on engineered cell lines, and the results were consistent and reproducible. I was particularly impressed with the proteins high purity.