user
menu
letter
Sign InRegister
langEnglisharrow
1/2
COA

Human TREM2 (19-157) Protein, Fc Tag

1/2
COA
Cat. No. / Size
Price
Availability
Qty
TR2-H5258-100ug
$380.00
In Stock - Delivery in 2-3 business days
TR2-H5258-1mg (500ug X 2)
$2,745.00
In Stock - Delivery in 2 weeks
TR2-H5258
Sub-Total :
$ 0
Customize Product Request Quote
Contact Us
Contact Us
Sub-Total:
$ 0
Request Quote
Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

Triggering receptor expressed on myeloid cells 2, TREM2, TREM-2

Source

Human TREM2 (19-157) Protein, Fc Tag (TR2-H5258) is expressed from human 293 cells (HEK293). It contains AA His 19 - His 157 (Accession # Q9NZC2-1).

Predicted N-terminus: His 19

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 42.1 kDa. The protein migrates as 50-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is a pivotal cell-surface receptor primarily found on microglia in the brain and macrophages in peripheral tissues. Acting as a lipid and amyloid-beta sensor, it signals through the adapter protein DAP12 to regulate immune responses, cell survival, and phagocytosis. In neurobiology, TREM2 is a major focus because its dysfunction is strongly linked to Alzheimer’s disease progression and impaired clearance of neurotoxic plaques.