GMP Human TGF-Beta 1 / TGFB1 Protein

TGF-β1 (Transforming Growth Factor-β1)​ is a key member of the TGF-β superfamily with broad biological functions, including regulation of cell growth, differentiation, apoptosis, and immunomodulation. In MSC culture, low concentrations of TGF-β1 help maintain MSC proliferation and stemness, while at high concentrations under specific induction conditions (e.g., chondrogenic differentiation), it serves as a critical inductive factor. In iPSC culture, TGF-β1/Activin-Nodal signaling is essential for maintaining pluripotency and is commonly used to drive differentiation toward endodermal and mesodermal lineages.

• Specific Stem Cell Expansion Driver​: Efficiently supports hPSC and MSC expansion while maintaining stemness over multiple passages.
• Reliable Large-Scale Supply: Ensures batch production capacity, supporting robust and consistent manufacturing scale-up.
• High Lot-to-Lot Consistency​: Ensures reliable and reproducible performance in every batch, supporting scalable applications.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

Ala-Leu-Asp-Thr-Asn-Tyr-Cys-Phe-Ser-Ser-Thr-Glu-Lys-Asn-Cys-Cys
(Routinely tested)

Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 100 mM HAC, pH3.0 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.