Biotinylated Human Tau-441 / 2N4R (1-441) Protein, His,Avitag™ (MALS verified)

AIDD‑Ready
Related Products: Cell line CHEK-ATP087, Streptavidin Series Products
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TAU-H81E3-100ug
$305.00
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TAU-H81E3-1mg
$2,046.00
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TAU-H81E3
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Synonyms

DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU

Source

Biotinylated Human Tau-441 / 2N4R (1-441) Protein, His,Avitag (TAU-H81E3) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8).

Predicted N-terminus: Met 1

Molecular Characterization

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

The protein has a calculated MW of 49.5 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Labeling

Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

Protein Ratio

Passed as determined by the SABA assay / HABA assay / binding ELISA.

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.

バックグランド

Tau 441 (2N4R) is the longest human brain tau isoform, containing two N-terminal inserts and four microtubule-binding repeats. It stabilizes neuronal microtubules, but its pathological hyperphosphorylation leads to paired helical filament aggregation. Tau 441 constitutes the core component of neurofibrillary tangles in Alzheimer's disease and related tauopathies.