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Human Tau-441 / 2N4R (P301S) Protein, His Tag (MALS verified)

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  • 分子别名（Synonym）

    DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

  • 表达区间及表达系统（Source）

    Human Tau-441 (P301S), His Tag (TAU-H5145) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8 (P301S)).

    Predicted N-terminus: Met

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    Tau Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 47.7 kDa. The protein migrates as 66 kDa under reducing (R) condition (SDS-PAGE).

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    90% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    Tau SDS-PAGE

    Human Tau-441 (P301S), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    Tau SEC-MALS

    The purity of Human Tau-441 (P301S), His Tag (Cat. No. TAU-H5145) is more than 85% and the molecular weight of this protein is around 53-65 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）-ELISA

    Tau ELISA

    Immobilized Human Tau-441 (P301S), His Tag (Cat. No. TAU-H5145) at 1 μg/mL (100 μL/well) can bind Tau Monoclonal Antibody with a linear range of 0.4-13 ng/mL (QC tested).

    Protocol

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背景介绍

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

前沿进展

 
药物研发进展
  • 英文全称：

    Microtubule-associated protein tau

  • 中文全称：

    微管相关蛋白tau

  • 种类：

  • 上市药物数量：

    1 详情

  • 临床药物数量：

    38 详情

  • 最高研发阶段：

    临床三期

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