选择语言
免费注册积分兑换
关注公众号
我的购物车
收藏产品

Human NPTX2 Protein, His Tag (MALS verified)

COAMS
DS
用户评价
货号-规格
价格
Qty.
合计0件 产品金额0
0
加入购物车
新品建议
增项建议

产品详情

  • 分子别名（Synonym）

    Neuronal pentraxin II,NP-II

  • 表达区间及表达系统（Source）

    Human NPTX2, His Tag (NP2-H52H6) is expressed from human 293 cells (HEK293). It contains AA Gly 16 - Leu 431 (Accession # P47972).

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    NPTX2 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 47.7 kDa. The protein migrates as 50-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    95% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

产品展示

  • 电泳（SDS-PAGE）

    NPTX2 SDS-PAGE

    Human NPTX2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    NPTX2 SEC-MALS

    The purity of Human NPTX2, His Tag (Cat. No. NP2-H52H6) is more than 85% and the molecular weight of this protein is around 315-335 kDa verified by SEC-MALS.

    Report

用户评价
发表评论

背景介绍

Neuronal Pentraxin 2 (NPTX2), also named neuronal activity-regulated pentraxin, is a secreted glycoprotein characterized by a cyclic multimeric structure. In vivo, NTPX2 exerts various neurological effects by combining with the transmembrane protein neuronal pen traxin receptor (NPTXR). NPTX2 was thought to play a vital role in transmitting neurotrans mitters and maintaining synaptic plasticity. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. 

前沿进展

 
联系我们
项目合作
查看更多项目
  • 产品SKU
  • 产品详情
  • 产品展示
  • 用户评价
  • 背景介绍