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1/2
COA

Human IL-2 R beta & IL-15 R alpha & IL-2 R gamma Protein, Twin Strep Tag&His Tag, low endotoxin (MALS verified)

1/2
COA
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ILG-H5284-100ug
$470.00
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ILG-H5284-1mg (500ug X 2)
$3,095.00
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ILG-H5284
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製品詳細
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  • 製品詳細
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Synonyms

IL-2 R beta & IL-15 R alpha & IL-2 R gamma

Source

Human IL-2 R beta & IL-15 R alpha & IL-2 R gamma Protein, Twin Strep Tag&His Tag (ILG-H5284) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Asp 239 (IL-2RB) & Ile 31 - Thr 205 (IL-15RA) & Leu 23 - Asn 254 (IL-2RG) (Accession # P14784-1 (IL-2RB) & Q13261-1 (IL-15RA) & P31785-1 (IL-2RG)).

Predicted N-terminus: Ala 27 & Ile 31

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

The protein has a calculated MW of 29.9 kDa & 52.6 kDa. The protein migrates as 37-39 kDa, 41-43 kDa and 95-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

The protein is designed as a heterodimer.

Endotoxin

Less than 0.01 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

バックグランド

Interleukin-2 receptor beta (IL-2Rβ, CD122) and the common gamma chain (γc, CD132) constitute the shared signaling modules for IL-2 and IL-15. IL-15 receptor alpha (IL-15Rα, CD215) is a specific high-affinity binding chain for IL-15. Its sushi domain mediates tight binding, and it can be shed as a soluble form. Unlike classical cytokine receptors, IL-15Rα often presents IL-15 in trans to adjacent cells expressing IL-2Rβ/γc, a process essential for the development, survival, and proliferation of natural killer (NK) cells and memory CD8+ T cells. IL-2 utilizes IL-2Rα, IL-2Rβ, and γc for high-affinity signaling. These three chains are members of the common gamma chain family. γc associates with JAK3, while IL-2Rβ recruits JAK1, both activating the STAT5 pathway to regulate immune responses.