GMP Human HGF Protein

HGF (Hepatocyte Growth Factor)​ is a pleiotropic cytokine primarily produced by mesenchymal stromal cells (MSCs) and known for its mitogenic, morphogenic, and anti‑fibrotic effects on epithelial and endothelial cells. In MSC culture, HGF enhances cell proliferation, migration, and survival while promoting the immunomodulatory and regenerative functions of MSCs, making it a key supplement in therapeutic MSC expansion protocols. In liver differentiation systems, HGF acts as a critical morphogen that drives the specification of hepatoblast‑like cells from definitive endoderm and supports their further maturation into functional hepatocyte‑like cells.

• Specific Hepatic & MSC Conditioning Driver​​: Efficiently supports hPSC-derived hepatocyte differentiation and functional pre-treatment of MSCs.
• Reliable Large-Scale Supply: Ensures batch production capacity, supporting robust and consistent manufacturing scale-up.
• High Lot-to-Lot Consistency​: Ensures reliable and reproducible performance in every batch, supporting scalable applications.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

GMP Human HGF Protein (GMP-HGFH28) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Ser 728 (Accession # P14210-1).

Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.