GMP Human GDNF Protein (E. coli)

GDNF is a potent trophic factor in the TGF-β superfamily, renowned for its powerful survival-promoting effects on specific neuronal populations, particularly midbrain dopaminergic and motor neurons. It is considered essential for the long-term survival and phenotypic stability of stem cell-derived dopaminergic neurons, a key cell type for Parkinson's disease research.

• Specific Neuronal Differentiation Driver​: Efficiently induces stem cell differentiation into neuronal progenitor cells and dopaminergic neurons.
• Safe Recombinant Expression​: Produced in an E. coli system to ensure high purity and enhanced safety profile.
• Cost-Effective Solution​: Achieves up to 50% cost reduction compared to conventional alternatives.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

Met-Ser-Pro-Asp-Lys-Gln-Met-Ala-Val-Leu-Pro-Arg-Arg-Glu-Arg
(Routinely tested)

Less than 10 EU/mg, tested by the rFC method in compliance with USP <86> and Ph. Eur. 2.6.32.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 20 mM Sodium Citrate, 150 mM NaCl, pH4.0 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.