GMP Human Flt-3 Ligand Protein (E. coli)

FLT3L (Fms-related tyrosine kinase 3 ligand)​ is a key cytokine that supports the proliferation, survival, and maintenance of early hematopoietic progenitors and dendritic cells. In HSC expansion systems, FLT3L promotes the self-renewal and output of multipotent progenitors. In iPSC-to-HSC differentiation protocols, it acts in the early hematopoietic specification stage to support the emergence of hemogenic endothelial cells and subsequent hematopoietic progenitor formation.

• Specific HSC Expansion Driver​: Efficiently supports hematopoietic stem cell expansion and hPSC-derived hematopoietic stem and progenitor cell differentiation, validated in multiple clinical trials and cell manufacturing processes.
• Reliable Large-Scale Supply: Ensures batch production capacity, supporting robust and consistent manufacturing scale-up.
• High Lot-to-Lot Consistency​: Ensures reliable and reproducible performance in every batch, supporting scalable applications.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

chain1：Met-Thr-Gln-Asp-Cys-Ser-Phe-Gln-His-Ser-Pro-Ile-Ser-Ser-Asp
chain2：Thr-Gln-Asp-Cys-Ser-Phe-Gln-His-Ser-Pro-Ile-Ser-Ser-Asp-Phe
(Routinely tested)

Less than 10 EU/mg, tested by the rFC method in compliance with USP <86> and Ph. Eur. 2.6.32.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.