GMP Biotinylated Human DLL4 Protein, His,Avitag™

DLL4​ (Delta-like ligand 4) is a Notch ligand primarily expressed in vascular endothelium and thymic epithelial cells. In iPSC differentiation toward T and NK cells, DLL4 plays a pivotal role in directing hematopoietic progenitors toward the lymphoid lineage by activating Notch signaling. Through sustained Notch pathway engagement, DLL4 drives T-lineage commitment, supports thymic progenitor expansion, and promotes functional maturation of both T cells and NK cells, making it essential for generating immune effector cells from pluripotent stem cells.

• Unique Clinical-Grade Offering: The only GMP-grade DLL4 available, validated in multiple clinical trials and cell manufacturing processes.
• Feeder-Free Culture Support: Enables feeder cell-independent culture systems, streamlining T/NK cell production workflows.
• Functional Differentiation Driver: Specifically supports efficient and directed differentiation toward T and NK cell lineages.
• Scalable and Reproducible: Features stringent quality control and high lot-to-lot consistency for seamless transition from research to clinical manufacturing.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

Ser-Gly-Val-Phe-Gln-Leu-Gln-Leu-Gln-Glu-Phe-Ile-Asn-Glu-Arg
(Routinely tested)

Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

As determined by Quantitative ELISA binding assay against streptavidin.

Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

6R (20 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.