GMP Human BDNF Protein (E. coli)

BDNF is a potent trophic factor in the TGF-β superfamily, renowned for its powerful survival-promoting effects on specific neuronal populations, particularly midbrain dopaminergic and motor neurons. It is considered essential for the long-term survival and phenotypic stability of stem cell-derived dopaminergic neurons, a key cell type for Parkinson's disease research.

• Specific Neuronal Differentiation Driver​: Efficiently induces stem cell differentiation into neuronal progenitor cells and dopaminergic neurons.
• Safe Recombinant Expression​: Produced in an E. coli system to ensure high purity and enhanced safety profile.
• Cost-Effective Solution​: Achieves up to 50% cost reduction compared to conventional alternatives.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

Met-His-Ser-Asp-Pro-Ala-Arg-Arg-Gly-Glu-Leu-Ser-Val-Cys-Asp
(Routinely tested)

Less than 10 EU/mg, tested by the rFC method in compliance with USP <86> and Ph. Eur. 2.6.32.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 0.1% TFA, pH2.2 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.