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Mouse APP / N-APP Protein, His Tag (MALS verified)

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  • 分子别名（Synonym）

    ABPP,APPI,Amyloid-beta A4 protein

  • 表达区间及表达系统（Source）

    Mouse N-APP, His Tag (APP-M52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 18 - Val 286 (Accession # P12023-1).

    Predicted N-terminus: Leu 18

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    APP Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 31.9 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    95% as determined by SDS-PAGE.

    90% as determined by SEC-MALS.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

产品展示

  • 电泳（SDS-PAGE）

    APP SDS-PAGE

    Mouse N-APP, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    APP SEC-MALS

    The purity of Mouse N-APP, His Tag (Cat. No. APP-M52H3) is more than 90% and the molecular weight of this protein is around 30-45 kDa verified by SEC-MALS.

    Report

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背景介绍

Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C102, which is subsequently cleaved by γ-secretase to release Aβ.

前沿进展

 
药物研发进展
  • 英文全称：

    Beta amyloid A4 protein

  • 中文全称：

    β-淀粉状蛋白A4

  • 种类：

  • 上市药物数量：

    12 详情

  • 临床药物数量：

    43 详情

  • 最高研发阶段：

    批准上市

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