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Human Alpha-Synuclein Protein, Fc Tag (MALS verified)

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  • 分子别名（Synonym）

    SNCA,NACP,PARK1,alpha-Synuclein

  • 表达区间及表达系统（Source）

    Human Alpha-Synuclein, Fc Tag (ALN-H5253) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 140 (Accession # P37840-1).

    Predicted N-terminus: Met 1

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    Alpha-Synuclein Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 40.9 kDa. The protein migrates as 47-52 kDa and 53-56 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    95% as determined by SDS-PAGE.

    90% as determined by SEC-MALS.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    Alpha-Synuclein SDS-PAGE

    Human Alpha-Synuclein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    Alpha-Synuclein SEC-MALS

    The purity of Human Alpha-Synuclein, Fc Tag (Cat. No. ALN-H5253) is more than 90% and the molecular weight of this protein is around 75-95 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）-ELISA

    Alpha-Synuclein ELISA

    Immobilized Human Alpha-Synuclein, Fc Tag (Cat. No. ALN-H5253) at 1 μg/mL (100 μL/well) can bind Anti-Synucelin alpha/beta Monoclonal Antibody with a linear range of 0.031-1 μg/mL (QC tested).

    Protocol

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背景介绍

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. This chaperone activity is important to sustain normal SRE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

前沿进展

 
药物研发进展
  • 英文全称：

    Synuclein alpha

  • 中文全称：

    α-突触核蛋白

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    23 详情

  • 最高研发阶段：

    临床三期

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