选择语言
免费注册积分兑换
关注公众号
我的购物车
收藏产品

Human Alpha-Synuclein (E46K) Protein, Tag Free (MALS verified)

COAMS
DS
用户评价
货号-规格
价格
Qty.
合计0件 产品金额0
0
加入购物车
新品建议
增项建议

产品详情

  • 分子别名（Synonym）

    SNCA,NACP,PARK1,alpha-Synuclein

  • 表达区间及表达系统（Source）

    Human Alpha-Synuclein (E46K), Tag Free (ALN-H5117) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (E46K)).

    Predicted N-terminus: Met 1

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    Alpha-Synuclein Structure

    This protein carries no "tag".

    The protein has a calculated MW of 14.5 kDa. The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    95% as determined by SDS-PAGE.

    95% as determined by SEC-MALS.

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in 50mM HEPES, 100mM NaCl, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

产品展示

  • 电泳（SDS-PAGE）

    Alpha-Synuclein SDS-PAGE

    Human Alpha-Synuclein (E46K), Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    Alpha-Synuclein SEC-MALS

    The purity of Human Alpha-Synuclein (E46K), Tag Free (Cat. No. ALN-H5117) is more than 95% and the molecular weight of this protein is around 13-20 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）-ELISA

    Alpha-Synuclein ELISA

    Immobilized Human Alpha-Synuclein (E46K), Tag Free (Cat. No. ALN-H5117) at 1 μg/mL (100 μL/well) can bind Synuclein alpha/beta Monoclonal Antibody with a linear range of 0.1-4 ng/mL (QC tested).

    Protocol

用户评价
发表评论

背景介绍

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

前沿进展

 
药物研发进展
  • 英文全称：

    Synuclein alpha

  • 中文全称：

    α-突触核蛋白

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    23 详情

  • 最高研发阶段：

    临床三期

联系我们
项目合作
查看更多项目
  • 产品SKU
  • 产品详情
  • 产品展示
  • 用户评价
  • 背景介绍