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HEK293/Human Mesothelin Stable Cell Line

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产品详情

    1. Genetically modified cell lines best reflect MOA (Mechanism of Action)
    2. Higher activity and larger assay window for robust and reproducible cell-based bioassay
    3. Comprehensive application data to support assay development and validation
    4. Full tracible record, stringent quality control and validated cell passage stability
    5. Parental cell line legally obtained from internationally recognized cell resource bank and commercially licensed
    6. Global commercial license assistance whenever regulatory filing is required

  • 描述（Description）

    The HEK293/Human Mesothelin Stable Cell Line was engineered to express the receptor full length human Mesothelin (Gene ID: 10232), used to mimic cancer target cells. Surface expression of Human Mesothelin was confirmed by flow cytometry.

  • 应用说明（Application）

    • Useful for cell-based Mesothelin binding assay

  • 生长特性（Growth Properties）

    Adherent

  • 筛选标记（Selection Marker）

    Puromycin (2 μg/mL)

  • 培养基（Complete Growth Medium）

    DMEM + 10% FBS

  • 冻存液（Freeze Medium）

    Serum-free cell cryopreservation medium

  • 装量（Quantity）

    1 vial contains at least 5×10^6 cells in 1 mL serum-free cryopreservation medium

  • 存储（Storage）

    Frozen in liquid nitrogen.

  • 支原体检测（Mycoplasma Testing）

    Negative

  • 无菌检测（Sterility Testing）

    Negative

  • 使用说明（Instructions for Use）

    See data sheet for detailed culturing and assay protocol.

产品展示

  • Receptor Assay

    Mesothelin FACS

    Expression analysis of human Mesothelin on HEK293/Human Mesothelin Stable Cell Line by FACS.
    Cell surface staining was performed on HEK293/Human Mesothelin Stable Cell Line or negative control cell using Alexa 647-labeled anti-human Mesothelin antibody.

    Protocol
*如有相关细胞池需求请联系我们

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背景介绍

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

前沿进展

 
药物研发进展
  • 英文全称：

    Mesothelin

  • 中文全称：

    间皮素

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    41 详情

  • 最高研发阶段：

    临床二期

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