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HEK293/Human Integrin alpha V beta 6 Stable Cell Line

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产品详情

    1. Genetically modified cell lines best reflect MOA (Mechanism of Action)
    2. Higher activity and larger assay window for robust and reproducible cell-based bioassay
    3. Comprehensive application data to support assay development and validation
    4. Full tracible record, stringent quality control and validated cell passage stability
    5. Parental cell line legally obtained from internationally recognized cell resource bank and commercially licensed
    6. Global commercial license assistance whenever regulatory filing is required

  • 描述（Description）

    The HEK293/Human Integrin alpha V beta 6 Stable Cell Line was engineered to express the receptors full length human Integrin alpha V (Gene ID: 3685) and Integrin beta 6 (Gene ID: 3694), used to mimic cancer target cells. Surface expression of human Integrin alpha V beta 6 was confirmed by flow cytometry.

  • 应用说明（Application）

    • Useful for cell-based Integrin alpha V beta 6 binding assay

  • 生长特性（Growth Properties）

    Adherent

  • 筛选标记（Selection Marker）

    Hygromycin B (20 μg/mL)

  • 培养基（Complete Growth Medium）

    DMEM + 10% FBS

  • 冻存液（Freeze Medium）

    Serum-free cell cryopreservation medium

  • 装量（Quantity）

    1 vial contains at least 5×10^6 cells in 1 mL serum-free cryopreservation medium

  • 存储（Storage）

    Frozen in liquid nitrogen.

  • 支原体检测（Mycoplasma Testing）

    Negative

  • 无菌检测（Sterility Testing）

    Negative

  • 使用说明（Instructions for Use）

    See data sheet for detailed culturing and assay protocol.

产品展示

  • Receptor Assay

    Integrin alpha V beta 6 FACS

    Expression analysis of human Integrin alpha V on HEK293/Human Integrin alpha V beta 6 Stable Cell Line by FACS.
    Cell surface staining was performed on HEK293/Human Integrin alpha V beta 6 Stable Cell Line or negative control cell using anti-human Integrin alpha V antibody followed by staining with FITC anti-mouse IgG Antibody.

    Protocol

  • Integrin alpha V beta 6 FACS

    Expression analysis of human Integrin beta 6 on HEK293/Human Integrin alpha V beta 6 Stable Cell Line by FACS.
    Cell surface staining was performed on HEK293/Human Integrin alpha V beta 6 Stable Cell Line or negative control cell using anti-human Integrin beta 6 antibody followed by staining with PE anti-human IgG Fc Antibody.

    Protocol
*如有相关细胞池需求请联系我们

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背景介绍

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

前沿进展

 
药物研发进展
  • 英文全称：

    Integrin alpha-V/beta-6

  • 中文全称：

    整合素α-V/β-6复合体

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    6 详情

  • 最高研发阶段：

    临床三期

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