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HEK293/Human ErbB2 Stable Cell Line

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产品详情

    1. Genetically modified cell lines best reflect MOA (Mechanism of Action)
    2. Higher activity and larger assay window for robust and reproducible cell-based bioassay
    3. Comprehensive application data to support assay development and validation
    4. Full tracible record, stringent quality control and validated cell passage stability
    5. Parental cell line legally obtained from internationally recognized cell resource bank and commercially licensed
    6. Global commercial license assistance whenever regulatory filing is required

  • 描述（Description）

    The HEK293/Human ErbB2 Stable Cell Line was engineered to express the receptor full length human ErbB2 (Gene ID: 2064), used to mimic cancer target cells. Surface expression of human ErbB2 was confirmed by flow cytometry.

  • 应用说明（Application）

    • Useful for cell-based ErbB2 binding assay

  • 生长特性（Growth Properties）

    Adherent

  • 筛选标记（Selection Marker）

    Puromycin (2 μg/mL)

  • 培养基（Complete Growth Medium）

    DMEM + 10% FBS

  • 冻存液（Freeze Medium）

    Serum-free cell cryopreservation medium

  • 装量（Quantity）

    1 vial contains at least 5×10^6 cells in 1 mL serum-free cryopreservation medium

  • 存储（Storage）

    Frozen in liquid nitrogen.

  • 支原体检测（Mycoplasma Testing）

    Negative

  • 无菌检测（Sterility Testing）

    Negative

  • 使用说明（Instructions for Use）

    See data sheet for detailed culturing and assay protocol.

产品展示

  • Receptor Assay

    Her2 FACS

    Expression analysis of human ErbB2 on HEK293/Human ErbB2 Stable Cell Line by FACS.
    Cell surface staining was performed on HEK293/Human ErbB2 Stable Cell Line or negative control cell using anti-human ErbB2 Antibody followed by staining with PE anti-human IgG Fc Antibody.

    Protocol
*如有相关细胞池需求请联系我们

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背景介绍

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.

前沿进展

 
药物研发进展
  • 英文全称：

    Receptor protein-tyrosine kinase erbB-2

  • 中文全称：

    受体蛋白酪氨酸激酶 erbB-2

  • 种类：

  • 上市药物数量：

    39 详情

  • 临床药物数量：

    201 详情

  • 最高研发阶段：

    批准上市

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