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HEK293/Human CCR8 Stable Cell Line

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    1. Genetically modified cell lines best reflect MOA (Mechanism of Action)
    2. Higher activity and larger assay window for robust and reproducible cell-based bioassay
    3. Comprehensive application data to support assay development and validation
    4. Full tracible record, stringent quality control and validated cell passage stability
    5. Parental cell line legally obtained from internationally recognized cell resource bank and commercially licensed
    6. Global commercial license assistance whenever regulatory filing is required

  • 描述（Description）

    The HEK293/Human CCR8 Stable Cell Line was engineered to express full length human CCR8 (Gene ID: 1237), used to mimic cancer target cells. Surface expression of human CCR8 was confirmed by flow cytometry.

  • 应用说明（Application）

    • Useful for cell-based CCR8 binding assay

  • 生长特性（Growth Properties）

    Adherent

  • 筛选标记（Selection Marker）

    Hygromycin B (20 μg/mL)

  • 培养基（Complete Growth Medium）

    DMEM + 10% FBS

  • 冻存液（Freeze Medium）

    Serum-free cell cryopreservation medium

  • 装量（Quantity）

    1 vial contains at least 5×10^6 cells in 1 mL serum-free cryopreservation medium

  • 存储（Storage）

    Frozen in liquid nitrogen.

  • 支原体检测（Mycoplasma Testing）

    Negative

  • 无菌检测（Sterility Testing）

    Negative

  • 使用说明（Instructions for Use）

    See data sheet for detailed culturing and assay protocol.

产品展示

  • Receptor Assay

    CCR8 FACS

    Expression analysis of human CCR8 on HEK293/Human CCR8 Stable Cell Line by FACS.
    Cell surface staining was performed on HEK293/Human CCR8 Stable Cell Line or negative control cell using anti-human CCR8 antibody followed by staining with PE anti-human IgG antibody.

    Protocol
*如有相关细胞池需求请联系我们

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背景介绍

This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs). CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine). It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.

前沿进展

 
药物研发进展
  • 英文全称：

    C-C chemokine receptor type 8

  • 中文全称：

    CC趋化因子受体8型

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    14 详情

  • 最高研发阶段：

    临床二期

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