Recombinant Monoclonal Anti-PD-L1 Antibody, Rabbit (5D3)

Recombinant Monoclonal Anti-PD-L1 Antibody, Rabbit (5D3) is a PD-L1 primary antibody for IHC application. PD-L1, is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. PD1 expression has been observed in a variety of cancers including melanoma and non-small cell lung cancer. The interaction of PD1/PDL1 is hypothesized to be a possible mechanism for the tumor to escape immune response. A number of checkpoint blockade inhibitors including pembrolizumab and nivolumab have been developed that target the PD1/PDL1 interaction in order to allow T-cells to recognize tumor cells without being deactivated by the tumor.

LEICA Experiment Protocol

Shipped at 4°C, Blue Ice. Store at +4°C for 14 days. Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot.