Alexa Fluor™ 647-Labeled Monoclonal Anti-FMC63 Antibody, Rabbit IgG (M4H08) (Non-Neutralizing) (0.03% Proclin)

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FM3-ABFMY2-25tests
$380.00
In Stock - Delivery in 2-3 business days
FM3-ABFMY2-200tests
$2,280.00
In Stock - Delivery in 2 weeks
FM3-ABFMY2
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Source

Monoclonal Anti-Mouse FMC63 antibody, Rabbit IgG1 (M4H08) is a rabbit monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

Antibody Type

Recombinant Monoclonal

Clone

M4H08

Isotype

Rabbit IgG, Kappa

Host Species

Rabbit

Reactivity

Human

Immunogen

Recombinant FMC63 scFv derived from HEK293 cells.

Conjugate

AF647

Excitation Wavelength: 640 nm

Emission Wavelength: 672 nm

Specificity

Specifically recognizes the antigen-recognition domain of FMC63 derived CARs.

Application

Flow Cytometry.

Recommended Dilution

1:20

Isotype Control

The isotype control is sold separately; please refer to Cat. No. DNP-AFM776 for product information.

Form

Lyophilized

Formulation

Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300, with trehalose as protectant.

Please contact us for customized product forms or formulations.

Reconstitution

Please refer to the Certificate of Analysis (CoA) for specific instructions.

Shipping

Lyophilized product is shipped at ambient temperature.

Storage

For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 24 months in lyophilized state;
  • -70°C for 12 months after reconstitution.
  • 2-8 °C for 12 months after reconstitution.
Notices

Product Specific Notices: For research use only.

バックグランド

FMC63 is an IgG2a mouse monoclonal antibody specific for CD19, which is a target for the immunotherapy of B lineage leukaemias and lymphomas. FMC63 scFv is the most commonly used ectodomain component of CD19-specific CARs. So far, most of reported CART19 trials contain the anti-CD19 scFv derived from FMC63, including the two FDA-approved CARs Kymriah and Yescarta.