Biotinylated Monoclonal Anti-Datopotamab Antibody, Mouse IgG1 (5D6)

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DAB-BLY2438a-25ug
$360.00
In Stock - Delivery in 2-3 business days
DAB-BLY2438a-200ug
$1,565.00
In Stock - Delivery in 2 weeks
DAB-BLY2438a
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Source

Chimeric Biotinylated Monoclonal Anti-Datopotamab Antibody, Mouse IgG1 (5D6) is recombinantly expressed in HEK293. It consists of mouse variable regions genetically fused to mouse IgG1 constant domains.

Antibody Type

Recombinant Monoclonal

Clone

5D6

Isotype

Mouse IgG1, Kappa

Host Species

Mouse

Conjugate

Biotinylated

Specificity

5D6 is an inhibitory anti-idiotype monoclonal antibody that specifically recognizes Datopotamab. No detectable binding to the tested human IgG1 controls, Bevacizumab, Cetuximab, Adalimumab, or TROP-2 was observed under the tested conditions. 5D6 inhibits the binding of Datopotamab to TROP-2.

Application
Application
Recommended Use / Performance
PK Assay Development
Recommended for use as the detection antibody in a sandwich ELISA for Datopotamab quantification during PK assay development, paired with Anti-Datopotamab Antibody (7D3) as the capture antibody.
(Recommended dilutions are for reference only. Optimal working concentrations may vary depending on your consumables, reagents, and assay conditions. We recommend optimizing for your specific system. No warranty is made regarding performance at any specific dilution.)
Purification

Protein A purified.

Aggregation

Less than 5%, as determined by SEC-MALS.

Concentration

Please refer to the Certificate of Analysis (CoA).

Form

Lyophilized

Formulation

Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

Please contact us for customized product forms or formulations.

Reconstitution

Please refer to the Certificate of Analysis (CoA) for specific instructions.

Shipping

Lyophilized product is shipped at ambient temperature.

Storage

For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
Notices

Product Specific Notices: For research use only.

バックグランド

A humanized monoclonal IgG1 antibody that binds to human trophoblast cell surface antigen 2 (TROP2), a transmembrane glycoprotein overexpressed on the surface of various epithelial tumor cells. Datopotamab contains human constant regions and variable regions (complementarity-determining regions) derived from a murine antibody specific for TROP2. It is produced in a Chinese Hamster Ovary (CHO) mammalian cell expression system and has a molecular weight of approximately 148 kilodaltons.