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VEGF R2

VEGF R2信息

英文名称:Vascular endothelial growth factor receptor 2上市药物数量17
中文名称血管内皮细胞生长因子受体2临床药物数量55
靶点别称EC:2.7.10.1，EC 2.7.10，VEGFR2，KDR，Vascular endothelial growth factor receptor 2，Fetal liver kinase 1，Kinase insert domain receptor，Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase)，Protein-Tyrosine Kinase Receptor Flk-1，FLK1，Tyrosine Kinase Growth Factor Receptor，Fetal Liver Kinase-1，Soluble VEGFR2，CD309 Antigen，EC 2.7.10.1，VEGFR-2，CD309，VEGFR，FLK-1，Vascular Endothelial Growth Factor Receptor-2最高研发阶段Phase 3 Clinical
英文名称:Vascular endothelial growth factor receptor 2
中文名称血管内皮细胞生长因子受体2
靶点别称EC:2.7.10.1，EC 2.7.10，VEGFR2，KDR，Vascular endothelial growth factor receptor 2，Fetal liver kinase 1，Kinase insert domain receptor，Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase)，Protein-Tyrosine Kinase Receptor Flk-1，FLK1，Tyrosine Kinase Growth Factor Receptor，Fetal Liver Kinase-1，Soluble VEGFR2，CD309 Antigen，EC 2.7.10.1，VEGFR-2，CD309，VEGFR，FLK-1，Vascular Endothelial Growth Factor Receptor-2
上市药物数量17
临床药物数量55
最高研发阶段Phase 3 Clinical

VEGF R2产品列表

  • 属性

    Protein (9)Cell (1)

  • 产品库

    在线 (11)

  • 物种

    Human (8)Rhesus macaque (1)Mouse (1)

  • 标签

    His Tag (5)Strep Tag (1)His Tag & Avi Tag (1)Mouse IgG Fc Tag (1)Fc Tag (1)- (2)

  • 标记

    Unconjugated (5)Biotin-labeled (1)FITC Labeled (1) (1)PE Labeled (1)APC Labeled (1)

共 10 项数据
  • 1

VEGF R2分子背景

Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.

VEGF R2分子别名

KDR,CD309,FLK1,VEGFR,VEGFR2

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