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TNF-alpha

TNF-alpha

TNF-alpha 詳細

Molecule Name
Tumor necrosis factor α
分子の別称
DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNFα
Drug Development Progress
治験薬の数60
市販薬剤の数69
研究＆開発段階Approved
ターゲットの別称
ICD1，Tumor necrosis factor，Tumor Necrosis Factor (TNF Superfamily， Member 2)，Tumor Necrosis Factor Ligand 1F，Tumor Necrosis Factor-Alpha，TNF Superfamily， Member 2，TNF， Macrophage-Derived，TNF， Monocyte-Derived，APC1 Protein，TNLG1F，DIF，NTF，TNF-a，TNF-alpha，ICD2，N-terminal fragment，TNF，Tumor necrosis factor ligand superfamily member 2，Cachectin，TNFSF2，TNFA
バックグランド
Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

TNF-alpha 製品リスト

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  • n***l2025-11-20
    GMP Human TNF-alpha Protein
    Love the consistent activity and freeze/thaw stability! very quick shipping
  • P***s2024-11-15
    Human TNF-alpha Protein, His Tag, active trimer, low endotoxin (MALS verified)
    We used this product to conduct binding affinity measurements with molecular modulators that were designed to bind to TNFα In Vitro. Experiment applied was Microscale Thermophoresis that detects binding and, with dilution series, binding affinity between TNFα and test molecule. Results showed low micro molar binding, which showed that TNFα and test molecule behaved as we hoped for! Now we ordered more of this protein for further tests