PTK7 詳細
Molecule Name
Protein-tyrosine kinase 7
分子の別称
PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7
Drug Development Progress
治験薬の数8
市販薬剤の数0
研究＆開発段階Phase 2 Clinical
ターゲットの別称
Colon carcinoma kinase 4，Inactive tyrosine-protein kinase 7，Tyrosine-protein kinase-like 7，CCK-4，PTK7，Protein Tyrosine Kinase 7 (Inactive)，Pseudo Tyrosine Kinase Receptor 7，PTK7 Protein Tyrosine Kinase 7，CCK4，Protein-Tyrosine Kinase 7，Protein Tyrosine Kinase 7
バックグランド
PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
PTK7 製品リスト
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1***62022-08-09Validated by SPR, measured monovalent affinity, anti-human FC chip, loaded diluted antibody, added diluted Folate R, His tag, with the affinity constant of 4 nM.