PSCA Overview
Molecule Name
Prostate stem cell antigen
Synonyms
PSCA,UNQ206,PRO232
Drug Development Progress
Drugs in Clinical Trials4
Approved Drugs0
Highest Development StagePhase 1 Clinical
Target Synonym
Prostate stem cell antigen，UNQ206/PRO232，PSCA，PRO232
Background
The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored protein, plays an important role in tumorigenesis. The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.
PSCA Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes (City of Hope Medical Center) | Phase 1 Clinical | City Of Hope National Medical Center | Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant | Details | |
| 124-iodine-labeled PSCA targeting minibody (ImaginAb) | Phase 1 Clinical | University Of California At Los Angeles | Pancreatic Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms | Details | |
| anti-PSMA/anti-PSCA CAR T-cell therapy PD-1 silent (Shanghai Unicar-Therapy Bio-medicine) | Phase 1 Clinical | Shanghai Unicar-Therapy Bio-Medicine Technology Co Ltd | Hormone-Resistant Prostate Neoplasms | Details | |
| MB-104 | MB-104; MB-105; MB-104 CS1 CAR; MB-105 PSCA CAR | Phase 1 Clinical | City Of Hope National Medical Center | Glioblastoma; Multiple Myeloma; Pancreatic Neoplasms; Prostatic Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms | Details |