Pleiotrophin 詳細
Molecule Name
Pleiotrophin
分子の別称
neurite growth-promoting factor 1,HARP,HBBM,HB-GAM,HBGF8,HBNF,HBNF1,HBNF-1,Heparin-binding brain mitogen,HNGF-8,NEGF1HBGF-8,OSF-1,Osteoblast-specific factor 1
Drug Development Progress
治験薬の数0
市販薬剤の数0
研究＆開発段階Preclinical
ターゲットの別称
HBNF，HBGF8，NEGF1，Heparin-Binding Neurite Outgrowth-Promoting Factor 1，Heparin-Binding Growth-Associated Molecule，Heparin-Binding Growth Factor 8，Heparin-Binding Brain Mitogen，Osteoblast-Specific Factor 1，HB-GAM，HBGF-8，HBNF-1，OSF-1，HBBM，Pleiotrophin (Heparin Binding Growth Factor 8， Neurite Growth-Promoting Factor 1)，Heparin-Binding Neurite Outgrowth Promoting Factor，Heparin-Binding Neurite Outgrowth-Promoting Factor，Neurite Growth-Promoting Factor 1，Heparin Affin Regulatory Protein，Heparin Binding Growth Factor 8，HBNF1，HARP
バックグランド
Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.
Pleiotrophin 製品リスト
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